Cidabetamide is a prescription anti-cancer drug, mainly used for peripheral T-cell lymphoma and specific types of breast cancer. It must be used under the guidance of a doctor, and it is strictly prohibited to buy and take it by yourself.
1、 Usage and dosage
1. PTCL patients
30mg (6 tablets) each time, twice a week.
The interval between two times should not be less than 3 days, such as Monday and Thursday.
2. Patients with breast cancer
20mg (4 tablets) each time, twice a week.
The interval should not be less than 3 days.
3. Usage
Take orally 30 minutes after meals to reduce gastrointestinal irritation.
Take the whole tablet in warm water without breaking, crushing, or chewing.
Missing service handling: Remember to replenish the service as soon as possible on the same day; The next day, I remembered not to take the supplements and continued with the original plan, prohibiting eating twice at once.
2、 Important precautions
1. Contraceptive requirements
Women of childbearing age must take effective contraceptive measures during and at least 3 months after discontinuing medication.
Contraception is also recommended for male patients during medication.
2. It is prohibited to adjust the dosage by oneself
When adverse reactions such as low platelets and fatigue occur, first check your blood and contact a doctor. The doctor will decide whether to reduce, suspend or stop the medication.
Common adjustment methods: 30mg → 25mg → 20mg, or pause and resume.
3. Drug interactions
Avoid co administration with strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, clarithromycin) or strong inducers (such as rifampicin, carbamazepine).
It will significantly affect the blood concentration of sildenafil.
Caution should be exercised when using other drugs that prolong the QT interval, such as certain antiarrhythmic drugs and antipsychotic drugs.
4. Regular monitoring of projects
Blood routine, liver and kidney function, electrolytes, electrocardiogram.
Handle any abnormalities in a timely manner, don't just "take it for granted".
3、 Storage and appearance
1. Store in a dark, sealed, and dry place below 25 ℃.
2. Stay away from children.
4、 Main adverse reactions (key monitoring items)1. Hematological toxicity - the most prominent
Thrombocytopenia (most common, occurring in most patients).
Decreased white blood cells/neutrophils.
Anemia
Regular blood routine check is required, usually every 1-2 weeks during the initial stage of treatment.
2. Gastrointestinal reactions
Nausea, vomiting, diarrhea, and decreased appetite.
Most cases are mild to moderate and can be treated accordingly.
3. Fatigue
Commonly, it may accumulate and worsen with the medication cycle.
4. QT interval prolongation
There is a risk of arrhythmia, and heart disease patients need to inform their doctors in advance and monitor their electrocardiograms.
5. Abnormal liver function
Elevated transaminase levels require regular liver function checks.
6. Other
Fever, increased risk of infection, changes in taste, electrolyte imbalances such as low potassium/low calcium.
