Fruquintinib Capsules is an antineoplastic drug mainly used for the treatment of metastatic colorectal cancer. Its common side effects include hypertension, proteinuria, hand-foot skin reaction, diarrhea, and liver function abnormalities. In severe cases, it may cause hemorrhage, gastrointestinal perforation, or thromboembolic events. During medication, it is necessary to strictly follow the doctor’s advice, monitor relevant indicators regularly, and seek medical attention promptly in case of discomfort.
I. Common Side Effects and Management
Hypertension
May be accompanied by dizziness and headache. Blood pressure should be monitored regularly, and antihypertensive drugs may be used if necessary.
Proteinuria
Manifested as increased foamy urine. Renal function needs to be evaluated through routine urine tests.
Hand-foot skin reaction
Redness, peeling or pain in the hands and feet. Moisturizer can be applied and friction should be avoided.
Diarrhea
Mild to moderate diarrhea can be relieved by dietary adjustment or antidiarrheal drugs; seek medical attention if it continues to worsen.
Fatigue and decreased appetite
Small and frequent meals are recommended to ensure nutritional intake, and supportive treatment may be given if necessary.
II. Severe Side Effects to Be Alert to
Hemorrhagic risk
Such as epistaxis, gingival bleeding, or visceral bleeding like hemoptysis and melena. The drug must be stopped immediately and medical treatment sought.
Gastrointestinal perforation
Sudden severe abdominal pain and fever, which may be life-threatening and require emergency treatment.
Thromboembolic events
Swelling of the lower extremities, chest pain or dyspnea, indicating deep vein thrombosis or pulmonary embolism, which requires urgent intervention.
Liver function abnormalities
Jaundice and elevated transaminase levels. Liver function should be checked regularly, and dose adjustment or drug withdrawal may be required if necessary.
III. Precautions for Medication
Evaluate underlying diseases (such as hypertension, liver and kidney disorders) before treatment, and recheck blood pressure, urine protein, and liver/renal function every 2–4 weeks during treatment.
Avoid concomitant use with anticoagulants (e.g., warfarin) or non-steroidal anti-inflammatory drugs to prevent an increased risk of bleeding.
Contraindicated in pregnant women, lactating women, and patients with hypersensitivity to any ingredient; dose reduction should be considered for elderly patients.
Strict compliance with medical advice is crucial. Patients must not adjust the dose or stop the drug without authorization.
Seek emergency medical treatment immediately in case of acute symptoms such as dyspnea, persistent vomiting, or confusion.
