The use of fruquintinib must be strictly guided by a doctor, with key focus on monitoring adverse reactions, drug interactions and lifestyle adjustments.
As a prescription drug for specific cancer treatments, it must be used regularly under medical supervision — do not adjust the dosage or stop taking it without medical advice.
I. Before Administration
Follow medical instructions
The dosage of fruquintinib is individualized based on your condition and physical status. Regular rechecks of liver and kidney function, blood routine and other tests are required during treatment.
Contraindicated populations
It is contraindicated in patients with hypersensitivity to any ingredient of the drug, those with moderate to severe liver or kidney dysfunction, and pregnant or lactating women.
Inform your doctor of your full health status in advance.
II. Common Adverse Reactions and Management
Hypertension
Monitor your blood pressure daily during treatment. Seek medical help promptly if you have headache, dizziness or other symptoms; your doctor may adjust the medication or prescribe antihypertensive drugs.
Proteinuria
Undergo regular urine tests. If abnormalities are found, your kidney function will be evaluated, and drug suspension may be necessary.
Diarrhea or abdominal pain
For mild diarrhea, adjust your diet (e.g., low-fiber, light meals). For severe cases, seek medical attention to avoid dehydration.
Bleeding risk
Watch for abnormal bleeding such as gum bleeding, black stool, etc. Emergency treatment is needed for severe bleeding.
III. Drug and Dietary Contraindications
Avoid concomitant use with strong CYP3A4 inhibitors or inducers (e.g., clarithromycin, rifampicin), which may affect efficacy or increase toxicity.
Take on an empty stomach
It is recommended to take the drug at least 1 hour before a meal or 2 hours after a meal, and avoid taking it with a high-fat meal.
Use grapefruit-related products with caution
Grapefruit and its products may interfere with drug metabolism and raise the risk of side effects.
IV. Lifestyle Precautions
Prevent infection
Immunity may decrease during treatment; avoid crowded places and pay attention to personal hygiene.
Sun protection
Some patients may develop skin reactions; take physical sun protection measures when going outdoors.
Contraception
People of childbearing potential must use effective contraception during treatment and after stopping the drug.
If you miss a dose, do not double the dose to make up for it — just take the next scheduled dose.
If severe side effects occur (e.g., dyspnea, persistent high fever), stop the drug immediately and seek emergency medical care.
Maintain close communication with your doctor during treatment and report any physical changes in time.
