Rezvilutamide Tablets are an androgen receptor inhibitor used in the treatment of prostate cancer. During treatment, grapefruit and grapefruit-containing products, as well as alcohol, should be avoided. Concomitant use with other medications (such as CYP3A4 inhibitors/inducers) requires caution. Specific contraindications must be strictly followed as prescribed by a doctor, with adjustments made based on individual patient conditions.
Foods and Medications to Avoid
1. Grapefruit and Related Citrus Fruits
Grapefruit, pomelo and similar fruits may inhibit the liver metabolic enzyme CYP3A4, leading to drug accumulation in the body and an increased risk of adverse reactions (such as fatigue and liver function abnormalities). Consumption of such fruits and their juices should be avoided during treatment.
2. Alcohol
Alcohol may increase the burden on the liver and exacerbate the risk of liver injury when combined with rezvilutamide. Alcohol consumption is not recommended throughout the treatment period.
3. Contraindicated Concomitant Medications
Strong CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole): may increase plasma concentrations of rezvilutamide and raise the risk of toxicity.
Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce the therapeutic efficacy of the drug.
Other antiandrogens or hormonal medications: concomitant use requires medical evaluation to avoid drug interactions.
4. High-Fat Diet
High-fat foods may affect the absorption of the drug. Avoid excessive intake of greasy foods before and after taking the medication. The specific dosing schedule (e.g., fasting or with food) should follow the doctor’s instructions.
Precautions
Medication Adjustment as Prescribed: Inform your doctor in advance if you need to take any other medications (including health supplements and traditional Chinese medicines). Do not use concomitant medications without medical advice.
Monitoring and Follow-Up: Undergo regular tests of liver function, blood routine and other indicators. Seek immediate medical attention if symptoms such as jaundice, loss of appetite, or abnormal bleeding occur.
Special Populations: Use with caution in patients with severe hepatic or renal impairment; the dosing regimen must be formulated by a doctor.
Summary
The specific contraindications of rezvilutamide are closely related to the individual condition and concomitant medications. Patients should strictly follow the prescription and proactively report adverse reactions to the doctor to ensure safe and effective treatment.
