Glumetinib, a MET inhibitor, is primarily indicated for the treatment of advanced non-small cell lung cancer (NSCLC) harboring MET gene abnormalities. Common side effects include gastrointestinal reactions, skin reactions, and liver function abnormalities, among others. Dosage adjustments should be made based on individual patient conditions, with strict adherence to medical advice for monitoring throughout treatment.
I. Common Side Effects and Manifestations
1. Gastrointestinal Reactions
Nausea, vomiting, and diarrhea: Mostly mild to moderate in severity; can be relieved through dietary modifications or medications.
Decreased appetite: Small, frequent meals are recommended; nutritional supplements may be necessary if needed.
2. Skin Reactions
Rash and pruritus: Mild cases can be managed with moisturizers or antihistamines; severe rash (e.g., accompanied by blisters or ulcers) requires temporary discontinuation of treatment and immediate medical attention.
3. Liver Function Abnormalities
Manifested as elevated transaminases; regular monitoring of liver function is essential. Hepatoprotective agents or dosage adjustments may be required if abnormalities occur.
II. Serious Side Effects Requiring Close Monitoring
Interstitial Lung Disease (ILD): Rare but potentially fatal. Immediate discontinuation of treatment and medical consultation are mandatory if symptoms such as dyspnea, worsening cough, or fever develop.
Cardiotoxicity
May cause arrhythmias or heart failure. Regular monitoring of electrocardiogram (ECG) and cardiac function is necessary.
Hematological Toxicity
Including anemia and thrombocytopenia; regular complete blood count (CBC) testing is required.
III. Precautions for Medication Use
Strict adherence to medical advice
Do not adjust dosage or discontinue treatment without physician approval. Regular re-evaluation of liver and kidney function, blood counts, and imaging studies is required during treatment.
Special populations
Caution is advised in patients with impaired liver or kidney function, pregnant women, or breastfeeding mothers. Prior communication with the treating physician is essential.
Medical consultation guidelines
Seek emergency medical care immediately if experiencing chest pain, intractable vomiting, jaundice, or severe allergic reactions (e.g., facial swelling).
It is recommended to record the onset time and specific symptoms of any adverse reactions during treatment to facilitate physician assessment of risks and optimization of the treatment plan.
