The recommended usual dose of ensartinib is 225 mg once daily, to be taken orally on an empty stomach (1 hour before a meal or 2 hours after a meal). The specific administration method shall be adjusted based on the patient's condition, tolerance and the doctor's instructions.
Usual Administration and Dosage
1.Standard dose
225 mg once daily. Swallow the tablet whole; do not crush, split or chew it.
2.Administration time
The medicine must be taken on an empty stomach, preferably 1 hour before a meal or 2 hours after a meal, so as to reduce the impact of food on drug absorption.
3.Treatment course
Continuous medication is required for a long term until disease progression or unacceptable toxic reactions occur.
Dose Adjustment
Doctors may adjust the dose according to the severity of adverse reactions in patients:
1.First dose reduction: Adjust to 200 mg once daily;
2.Second dose reduction: Adjust to 150 mg once daily;
3.If tolerance is still not achieved: Medication should be suspended or permanently discontinued.
Common adverse reactions requiring dose adjustment include elevated liver enzymes, interstitial lung disease, severe skin rash, etc.
Medication in Special Populations
1.Hepatic and renal impairment
Patients with mild to moderate hepatic impairment do not need dose adjustment, while those with severe hepatic impairment should use the medicine with caution; patients with renal impairment generally do not require dose adjustment, but close monitoring is needed.
2.Elderly patients
No separate dose adjustment is required due to age, but individual tolerance should be closely monitored.
3.Pediatric and adolescent patients
The safety and efficacy have not been confirmed, and the medicine should be used strictly in accordance with the doctor's evaluation.
Precautions
1.Take the medicine as prescribed
Ensartinib is a prescription drug. It must be used strictly in accordance with the dose and course of treatment prescribed by the doctor. Do not increase, decrease the dose or discontinue the medicine without authorization.
2.Missed dose management
If a dose is missed and more than 12 hours remain until the next scheduled dose, the missed dose can be taken immediately; otherwise, skip the missed dose and take the next dose as planned.
3.Adverse reaction monitoring
During the treatment period, it is necessary to conduct regular examinations of liver function, blood routine and monitor pulmonary symptoms. Seek medical attention promptly if symptoms such as dyspnea and persistent fever occur.
Medical Guidance
During the medication period, if severe adverse reactions occur (such as severe liver injury, persistent diarrhea or arrhythmia), contact the doctor immediately and adjust the treatment plan. It is recommended to carry out the initial medication or dose adjustment stage under the guidance of professional medical institutions.
