The standard dosage of Anlotinib is 12 mg orally once daily before breakfast, administered in a regimen of "2 weeks on treatment followed by 1 week off," with 21 days constituting one treatment cycle. The specific dosage will be adjusted under medical guidance based on adverse reactions and must not be increased or decreased independently.
Standard Dosage and Administration
Starting Dosage: 12 mg orally once daily.
Timing of Administration: Take orally before breakfast, preferably at a fixed time each day.
Dosing Schedule: 2 consecutive weeks on treatment followed by 1 week off, forming a 3-week (21-day) cycle.
Duration of Treatment: Continue treatment until disease progression or unacceptable adverse reactions occur.
Principles of Dose Modification
First Adjustment: 10 mg once daily, also administered as 2 weeks on and 1 week off.
Second Adjustment: 8 mg once daily, also administered as 2 weeks on and 1 week off.
If Still Intolerable: If the 8 mg dose remains intolerable, permanently discontinue treatment.
Prerequisite for Adjustment: Must be determined by a physician based on the severity of adverse reactions; self-adjusting the dose is strictly prohibited.
Missed Doses and Precautions
Handling Missed Doses: If the time remaining until the next dose is less than 12 hours, skip the missed dose to avoid doubling up.
Prescription Requirements: Anlotinib is an antineoplastic prescription drug and must be used under the guidance of a physician experienced in cancer treatment.
Key Monitoring Parameters: Blood pressure, routine urinalysis, and bleeding tendencies must be monitored during treatment; seek prompt medical attention if significant discomfort occurs.
